Effect of Diospyros kaki extracts on atopic dermatitis-related cytokines

Chang-Eui Hong, Su-Yun Lyu*
Author Information & Copyright
1Sunchon National University, Suncheon 57922, Korea.
*Corresponding Author: Su-Yun Lyu, Phone: 01032496083. E-mail:

© Copyright 2023 Korean Society for Food Science of Animal Resources. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Sep 09, 2023; Revised: Oct 11, 2023; Accepted: Oct 16, 2023

Published Online: Oct 16, 2023


Diospyros kaki, also known as persimmon, has been used in traditional medicine for its potential health benefits. In this study, we employed 1,3-butylene glycol extract (DBG) and ethanol extract (DET) to investigate their anti-atopic dermatitis activity. The results showed that DBG and DET were effective in reducing atopic dermatitis-related cytokines such as IL-8, TNF-α, and IgE. Additionally, they upregulated the Th1 cytokine, IL-2. Furthermore, both extracts exhibited significant superoxide dismutase (SOD)-like activities. These findings collectively suggest that D. kaki extracts may be beneficial in improving atopic dermatitis due to their immunomodulatory and antioxidant properties.

Keywords: atopic dermatitis; Diospyros kaki; cytokine