Effect of Diospyros kaki extracts on atopic dermatitis-related cytokines
Received: Sep 09, 2023; Revised: Oct 11, 2023; Accepted: Oct 16, 2023
Published Online: Oct 16, 2023
Diospyros kaki, also known as persimmon, has been used in traditional medicine for its potential health benefits. In this study, we employed 1,3-butylene glycol extract (DBG) and ethanol extract (DET) to investigate their anti-atopic dermatitis activity. The results showed that DBG and DET were effective in reducing atopic dermatitis-related cytokines such as IL-8, TNF-α, and IgE. Additionally, they upregulated the Th1 cytokine, IL-2. Furthermore, both extracts exhibited significant superoxide dismutase (SOD)-like activities. These findings collectively suggest that D. kaki extracts may be beneficial in improving atopic dermatitis due to their immunomodulatory and antioxidant properties.