Article

In vitro induction effects of Commiphora molmo (Myrrh) extracts on cell migration through anti-inflammatory activity

Hyun Joo Ha, Seung-Jae Lee*, Seon Gyeong Bak, Seung Woong Lee, Sun Hee Cheong
Author Information & Copyright
1Dong-A University, Busan 49315, Korea.
2Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup 56212, Korea.
3Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup 56212, Korea.
*Corresponding Author: Seung-Jae Lee, Phone: +82-63-570-5267. E-mail: seung99@kribb.re.kr.

© Copyright 2020 Korean Society for Food Science of Animal Resources. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: May 11, 2020; Revised: Jun 12, 2020; Accepted: Jun 17, 2020

Published Online: Jun 30, 2020

Abstract

Commiphora molmo (Myrrh) contains various biological activities. However, the underlying molecular mechanisms in cells remain unknown. The purpose of this study was to confirm the efficacy of inhibiting nitric oxide (NO) production induced by lipopolysaccharides (LPS) on J774 macrophage cells of myrrh, and additionally regulatory effects of perform wound healing. Further, vascular endothelial growth factor (VEGF), phosphorylation of signal transducer and activator of transcription3 (p-STAT3) and Janus kinase 2 (p-JAK2) levels in macrophage cells were regulated in the presence of myrrh extract. Based on the above results, myrrh is thought to provide basic data on anti-inflammatory properties through interleukin 6 (IL-6) inhibitory activity and regulatory effects of cell migration.

Keywords: Commiphora molmo; Anti-inflammation; Cell migration; Wound healing