In vitro induction effects of Commiphora molmo (Myrrh) extracts on cell migration through anti-inflammatory activity
Received: May 11, 2020; Revised: Jun 12, 2020; Accepted: Jun 17, 2020
Published Online: Jun 30, 2020
Commiphora molmo (Myrrh) contains various biological activities. However, the underlying molecular mechanisms in cells remain unknown. The purpose of this study was to confirm the efficacy of inhibiting nitric oxide (NO) production induced by lipopolysaccharides (LPS) on J774 macrophage cells of myrrh, and additionally regulatory effects of perform wound healing. Further, vascular endothelial growth factor (VEGF), phosphorylation of signal transducer and activator of transcription3 (p-STAT3) and Janus kinase 2 (p-JAK2) levels in macrophage cells were regulated in the presence of myrrh extract. Based on the above results, myrrh is thought to provide basic data on anti-inflammatory properties through interleukin 6 (IL-6) inhibitory activity and regulatory effects of cell migration.